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Operation timed out from messagelabs.com

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I need a solution

Email transmission can't be completed from our mail server [210.135.65.21].

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connect to cluster1.us.messagelabs.com[216.82.249.179]: Operation timed out (port 25)

connect to cluster4.us.messagelabs.com[216.82.251.34]: Operation timed out (port 25)

connect to cluster6out.us.messagelabs.com[216.82.251.38]: Operation timed out (port 25)

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I checked this IP by Symantec blocklist "http://ipremoval.sms.symantec.com/lookup/",

but does not have a negative reputation.

How can this problem be resolved?

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