501 Connection rejected by policy

Hello,

I have an email system on IP: 104.243.65.51

My users and I have been getting some mails returning with: "501 Connection rejected by policy"

The server is not black listed, implements DKIM, SPF, DMARC and on http://ipremoval.sms.symantec.com/lookup/ it reports: The IP address you submitted, 104.243.65.51, does not have a negative reputation and therefore cannot be submitted for investigation.

Could you please check why this address is getting blocked?

Thanks Michel